NCT03253172

Potassium Supplementation in CKD

Renoprotective Effects of Potassium Supplementation in Chronic Kidney Disease (CKD)

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 532 (estimated)
• Sponsor: Erasmus Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The current high-sodium, low-potassium diet contributes to the high prevalence of high blood pressure (hypertension). Indeed, the anti-hypertensive effects of potassium supplementation are well-established. Hypertension is even more prevalent and resistant in patients with chronic kidney disease (CKD) and contributes to further decline in kidney function. Four recent epidemiological studies (published 2014 - 2016) showed that higher dietary potassium intake was associated with better renal outcomes. All studies recommended an intervention study with potassium supplementation in patients with CKD, but this has not been performed. The aim of this study is to study the renoprotective effect of potassium supplementation in patients with CKD (stage 3b or 4, i.e. estimated glomerular filtration rate \[eGFR\] 15 - 45 ml/min/1.73 m2).

Conditions

• Renal Insufficiency, Chronic
• Potassium Depletion
• Hypertension
• Hyperkalemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Potassium Chloride	Two potassium supplements with varying anions.
DIETARY_SUPPLEMENT	Potassium Citrate	Potassium Citrate
DIETARY_SUPPLEMENT	Placebo	Placebo

Timeline

• Start date: 2017-07-01
• Primary completion: 2026-05-01
• Completion: 2026-10-01
• First posted: 2017-08-17
• Last updated: 2026-02-12

Locations

4 sites across 1 country: Netherlands