NCT03253107

Predicting Biomarker of Gastric Cancer Chemotherapy Response

Postgenome-based Systemic Discovery of Strong Biomarkers Predict Gastric Cancer Chemotherapy Response

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 800 (estimated)
• Sponsor: Kyungpook National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

* discovery and validation of biomarker predicting gastric cancer chemotherapy response * Analysis for expression level of mRNA using Next generation sequencing in gastric cancer tissue by chemotherapy response * Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response * Validation of mRNA and miRNA using qRT-PCR in multiple independent cohort * Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response

Detailed description

* discovery and validation of biomarker predicting gastric cancer chemotherapy response * Analysis for expression level of mRNA in fresh frozen gastric cancer tissue by chemotherapy response (A) method of mRNA expression measurement: RNA sequencing (B) study group Palliative chemotherapy (inoperable patients) * institutional primary Chemotherapy regimen (XP or Xelox) 1. response group 2. progression group Post-OP adjuvant chemotherapy * institutional primary Chemotherapy regimen 1. complete response group 2. non-responder group <!-- --> 1. and 2) groups: age, sex, regimen matched * Analysis for expression level of miRNA using Next generation sequencing in gastric cancer tissue and blood by chemotherapy response (A) method of mRNA expression measurement: RNA sequencing (B) study group * the same patients in mRNA sequencing * Validation of mRNA and miRNA in multiple independent cohort method of measurement of RNA expression: qRT-PCR * Biological biomarkers-clinical factor combined prediction model of gastric cancer chemotherapy response combination of biologic biomarker and clinical factors to predict the chemotherapy response in gastric cancer

Conditions

• Gastric Cancer
• Chemotherapy Effect
• Predictive Cancer Model

Interventions

Type	Name	Description
DRUG	Chemotherapy	Institutinal standard chemotherapy as first line : XP (xeloda + cisplantin) or Xelox (xeloda+oxaliplitan) +/- Herceptin

Timeline

• Start date: 2015-11-30
• Primary completion: 2024-12-31
• Completion: 2024-12-31
• First posted: 2017-08-17
• Last updated: 2023-10-04

Locations

1 site across 1 country: South Korea