NCT03252626

Study on the Efficacy of Alprostadil Injection in Patients With Acute Ischemic Stroke

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 950 (estimated)
• Sponsor: The First Hospital of Jilin University · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

Ischemic stroke has a variety of treatments and currently drug therapy is one of the main treatments.A number of clinical studies have proved that alprostadil (PGE1) has pharmacological effects of significant dilation of blood vessels, inhibition of plate aggregation, anti-atherosclerosis and increased cerebral blood flow.Evaluate the 90-days efficacy by comparing two groups of patients'(one with alprostadil,another with placebo) mRS.

Conditions

• Stroke

Interventions

Type	Name	Description
DRUG	Alprostadil	Alprostadil injection USP for intravascular infusion contains 500 micrograms Alprostadil, more commonly known as prostaglandin E1. Vasodilation, inhibition of platelet aggregation are among the most notable of these effects. 2ml Alprostadil injection added into 10ml 0.9% saline.
DRUG	Normal saline	2ml normal saline injection added into 10ml 0.9% saline.

Timeline

• Start date: 2024-04-18
• Primary completion: 2024-12-31
• Completion: 2025-06-30
• First posted: 2017-08-17
• Last updated: 2024-04-01