NCT03250078

A Pancreatic Cancer Screening Study in Hereditary High Risk Individuals

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Nuvance Health · Academic / Other
• Sex: All
• Age: 50 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

The main goal of this study is to screen and detect pancreatic cancer and precursor lesions in individuals with a strong family history or genetic predisposition to pancreatic cancer. Magnetic Resonance Imaging and Magnetic cholangiopancreatography (MRI/MRCP) will be utilized to screen for early stage pancreatic cancer or precursor lesions. Participants will be asked to donate a blood sample at specific intervals for the creation of a bio-bank necessary for the development of a blood based screening test for Pancreatic Cancer.

Detailed description

Individuals 50 years of age and older who have a family history of pancreatic cancer will be recruited through the offices of primary care physicians and endocrinologists. Those meeting initial criteria will meet with a research APRN and will undergo a secondary screen to determine eligibility. Individuals enrolled in the study will undergo a five-minute psychological survey and donation of a blood sample for bio-bank analysis every 6 months for 3 years. MRI will be performed annually for 3 years (4 in total). Any abnormalities on MRI will be reviewed by a multi-disciplinary tumor board and discussed with the participant. The costs of MRI will be covered by the study.

Conditions

• Pancreatic Neoplasms

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	MRI/MRCP	An MRI/MRCP plus IV gadolinium contrast with high resolution imaging of the pancreas will be performed annually

Timeline

• Start date: 2016-11-01
• Primary completion: 2030-11-01
• Completion: 2030-11-01
• First posted: 2017-08-15
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States