NCT03249012

Quality of Life Related to Different Treatment Protocols for Post-thyroidectomy Hypoparathyroidism

Comparing the Quality of Life Associated With Empiric Calcium Repletion and Parathormone (PTH) Based Calcium Repletion for Post Thyroidectomy Hypoparathyroidism

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (estimated)
• Sponsor: CHU de Quebec-Universite Laval · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to compare two different protocols commonly used in the management of post thyroidectomy hypoparathyroidism : PTH based calcium repletion and empiric repletion. The investigators aim to compare the quality of life associated with these two protocols in a randomized trial.

Detailed description

Enrolled patients will be randomized in two treatment groups. In group 1, all patients will receive calcium carbonate and calcitriol in the post-operative period, with standardized weaning. In group 2, patients will be prescribed calcium carbonate and calcitriol only if their post-operative PTH dosage is 25% or less of the pre-operative dosage, or if post-operative PTH is inferior to 15. The Short-Form 36 (SF-36) questionnaire (French canadian version) will be used to assess quality of life pre-operatively and at post-op week 1 and 4. Symptoms of hypocalcemia and adverse effects of calcium carbonate and calcitriol will be monitored at week 1 and 4.

Conditions

• Hypoparathyroidism Postprocedural
• Quality of Life

Interventions

Type	Name	Description
OTHER	Empiric use of Calcium Carbonate and Calcitriol	Empiric calcium carbonate and calcitriol repletion
OTHER	PTH based Calcium Carbonate and Calcitriol repletion	PTH based treatment

Timeline

• Start date: 2017-09-01
• Primary completion: 2025-09-01
• Completion: 2025-09-01
• First posted: 2017-08-15
• Last updated: 2024-08-28

Locations

1 site across 1 country: Canada