NCT03241875

Effects of Preoperative Gabapentin Versus Pregabalin on Shoulder Pain After Laparoscopic Cholecystectomy

Effects of Preoperative Gabapentin Versus Pregabalin on Shoulder Pain After Laparoscopic Cholecystectomy. A Randomized Clinical Trial

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Faculty of Medicine, Sousse · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the effect of premedication with pregabalin or gabapentin versus placebo on postoperative shoulder pain after laparoscopic cholecystectomy.

Detailed description

Preoperative premedication with gabapentins reduces preoperative anxiety, stress response to surgical stimuli, decreases anesthetic use. The incidence of postoperative nausea and vomiting appears to be decreased. The other desired effect of gabapentins is the reduction in the intensity of postoperative pain after laparoscopic surgery.

Conditions

• Pain, Postoperative
• Cholecystectomy, Laparoscopic

Interventions

Type	Name	Description
DRUG	Pregabalin 75mg	In this group, premedication is performed with 2 capsules of pregabalin 2 hours before anesthetic induction.
DRUG	Gabapentin 300mg	In this group, premedication is performed with 2 capsules of gabapentin 2 hours before anesthetic induction.
DRUG	Placebo oral capsule	In this group, no premedication is performed, but patients receive 2 capsules of placebo 2 hours before anesthetic induction.

Timeline

• Start date: 2016-12-01
• Primary completion: 2017-08-30
• Completion: 2017-09-28
• First posted: 2017-08-08
• Last updated: 2017-10-02

Locations

1 site across 1 country: Tunisia