NCT03241303

Delineation of the Role of Glucagon-like Peptide-1 Signalling in Relation to Increased Carbohydrate Content in the Distal Small Intestines

The Role of Glucagon-like Peptide-1 Receptor Signalling in the Glucose-lowering Effect of Increased Carbohydrate Content in the Distal Small Intestines After Meal Ingestion in Patients With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Investigation of GLP-1 signalling in the glucose-lowering effect of increased carbohydrate content in the distal small intestines induced by alpha-glucosidase inhibition during meal ingestion in patients with type 2 diabetes

Detailed description

The primary aim of the study is to investigate whether GLP-1 released as a result of increased carbohydrate content in the distal and L cell-rich part of the small intestine after a meal affects postprandial plasma glucose levels in patients with type 2 diabetes. This will be done by applying an alpha-glucosidase inhibitor (to increase the postprandial carbohydrate content in the distal small intestine) and the specific GLP-1 receptor antagonist exendin(9-39) (to isolate any GLP-1-mediated effects) during meal tests in patients with type 2 diabetes.

Conditions

• Glucose Metabolism Disorders

Interventions

Type	Name	Description
DRUG	Acarbose	Glucobay tablets on experimental day.
DRUG	Placebo Oral Tablet	Placebo tablets on experimental day.
DRUG	Exendin (9-39)	Infusion of GLP-1 receptor antagonist as a study tool to block GLP-1 activity on experimental day.
DRUG	Placebo Saline	9 mg/ml placebo saline infusion on experimental day.

Timeline

• Start date: 2017-08-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2017-08-07
• Last updated: 2020-03-26

Locations

1 site across 1 country: Denmark