NCT03239678

Safe Time for Apnea After Preoxygenation

Safe Time for Apnea After Preoxygenation With Different Oxygen Concentration During the Induction of General Anesthesia

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (actual)
• Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

The use of 100% oxygen during the induction of general anesthesia is always preferable to have enough time to secure the airway by endotracheal intubation, because preoxygenation with a low oxygen concentration may reduce the safe time for apnea. However, using a low oxygen concentration during preoxygenation might prevent the formation of atelectasis. There is still no clear conclusion about the best oxygen concentration for preoxygenation. Our study is designed to evaluate the safety of preoxygenation with 80%, 60%, 40%, 30% and 21% oxygen by the safe time for apnea during the induction of general anesthesia.

Detailed description

We decide to add 3 groups (80%, 60%, and 40% oxygen) in our study to fully evaluate the safety of preoxygenation with different oxygen concentration. Zijia Li 2018.3.2

Conditions

• Anesthesia, General

Interventions

Type	Name	Description
DRUG	100% Oxygen	Conventional preoxygenation with 100% oxygen
DRUG	30% Oxygen	preoxygenation with 30% oxygen
DRUG	21% Oxygen	preoxygenation with 21% oxygen
DRUG	40% Oxygen	preoxygenation with 40% oxygen
DRUG	60% Oxygen	preoxygenation with 60% oxygen
DRUG	80% Oxygen	preoxygenation with 80% oxygen

Timeline

• Start date: 2017-08-01
• Primary completion: 2017-12-30
• Completion: 2017-12-30
• First posted: 2017-08-04
• Last updated: 2022-11-29

Locations

1 site across 1 country: China