NCT03238833

Poor Ovarian Responders Undergoing IVF Using Luteal Ovarian Stimulation Versus Follicular Ovarian Stimulation

Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 96 (actual)
• Sponsor: Kaohsiung Veterans General Hospital. · Academic / Other
• Sex: Female
• Age: 30 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The investigators attempted to compare the clinical outcomes and cumulus genes expression in poor ovarian responders undergoing luteal ovarian stimulation or follicular ovarian stimulation in in vitro fertilization cycles.

Detailed description

Multiple follicular wave theory proposed by Baerwald et al. implied that follicle recruitment may occur in the luteal phase of menstrual cycle. Therefore, luteal phase ovarian stimulation (LPOS) was considered as a potential feasible stimulation method during in vitro fertilization (IVF) cycle. In the beginning, in order to avoid delaying cancer treatment, LPOS was applied for fertility preservation of cancer patients, showing no difference in numbers of oocyte retrieved, mature oocytes and fertilization rate between luteal or follicular phase stimulation. In the recent, LPOS was used for infertility women, suggesting that LPOS owned quite good IVF outcomes. In previous studies, premature luteinizing hormone (LH) surge, a major reason worsening ovarian quality in poor ovarian responders (PORs), was seldom found in LPOS. High progesterone in luteal phase may aid in suppressing premature LH surge. An updated research claimed that numbers of oocyte retrieved, mature oocytes and fertilized oocytes in LPOS significantly increased when compared to follicular ovarian stimulation. Therefore, the investigators presumed that LPOS was a more effective method than follicular stimulation in PORs.

Conditions

• Fertilization in Vitro

Interventions

Type	Name	Description
OTHER	luteal ovarian stimulation	In the in vitro fertilization cycle, controlled ovarian stimulation was started since the luteal phase.
OTHER	follicular ovarian stimulation	In the in vitro fertilization cycle, controlled ovarian stimulation was started since the follicular phase.

Timeline

• Start date: 2017-05-03
• Primary completion: 2019-12-31
• Completion: 2019-12-31
• First posted: 2017-08-03
• Last updated: 2021-02-18

Locations

1 site across 1 country: Taiwan