NCT03238430

Management of Pain Post Hepatectomy : Infiltration of Local Anesthetics Versus Continuous Spinal Analgesia .

• Status: Completed
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 186 (actual)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Analgesia in liver surgery is a challenge, postoperative coagulopathy risk raises fears an epidural haematoma formation following the epidural analgesia, "gold standard" in major abdominal surgery. The spinal analgesia and/or continuous wound infiltration of local anesthetics constitute so an alternative. The study will compare the continuous infiltration of local anesthetics and rachianalgesia in terms of decreased postoperative morphine consumption and incidences of chronic postoperative pain at 3 and 6 months after hepatic surgery compared to the control group.

Conditions

• Pain, Postoperative

Interventions

Type	Name	Description
DRUG	intrathecal morphine	A single intrathecal injection of 300 micrograms of Morphine preoperatively, just before induction.
DRUG	Morphine PCA	a postoperative Morphine PCA
DRUG	Ropivacaine infiltration	Ropivacaine 2mg / ml at the rate of 8ml per hour via a multiperforated catheter with connector after bolus of 20 ml

Timeline

• Start date: 2015-05-20
• Primary completion: 2019-05-25
• Completion: 2019-05-25
• First posted: 2017-08-03
• Last updated: 2025-12-22

Locations

1 site across 1 country: France