NCT03237221

Clinical Characteristics, Treatment and Prognosis of Chest Tightness Variant Asthma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 76 (actual)
• Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University · Academic / Other
• Sex: All
• Age: 14 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually occurring at night or early morning. However, there are still some patients with only persistent clinical manifestations of chest tightness. Concerned about this group of patients, we presented a subgroup of bronchial asthma, namely, chest tightness variant asthma (CTVA). This asthma subgroup usually lacks asthma-specific clinical features such as wheezing, shortness of breath, wheezing, and therefore often misdiagnosed for a long time. In order to further understand the clinical characteristics, pathogenesis, and prognosis of patients with CTVA, we conducted a national multicenter observation study to further understand CTVA. Finally, we plan to clarify whether CTVA is a relatively independent asthma phenotype. Meanwhile, reducing misdiagnosis and perform an appropriate treatment of CTVA.

Conditions

• Asthma
• Chest Syndrome
• Clinical Anxiety
• Clinical Depression
• Lung Function
• Quality of Life
• Eosinophilia
• Nitric Oxide
• Airway Responsiveness
• Induced Sputum

Interventions

Type	Name	Description
DRUG	Treat patient according to Global Initiative for Asthma (GINA) guideline	Treat patient according to Global Initiative for Asthma (GINA) guideline

Timeline

• Start date: 2015-03-01
• Primary completion: 2019-12-12
• Completion: 2020-10-23
• First posted: 2017-08-02
• Last updated: 2020-10-27

Locations

34 sites across 1 country: China