Trials / Withdrawn
WithdrawnNCT03236558
The Role of the Thymus in Type I Diabetes.
Thymic Generation of Regulatory T Lymphocytes in Type I Diabetes Patients.
- Status
- Withdrawn
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 0 (actual)
- Sponsor
- University Hospital, Toulouse · Academic / Other
- Sex
- All
- Age
- 6 Years – 12 Years
- Healthy volunteers
- Accepted
Summary
Regulatory T lymphocytes play a major role in the protection from autoimmune pathology. Defects in immunosuppression mediated by these cells is therefore suspected to contribute to these diseases. This issue has very little been studied in humans.Regulatory T cells emigrated from the thymus will be isolated from the blood of patients and healthy controls. The repertoire of antigen-receptors will be analysed by high throughput sequencing and its diversity estimated using appropriate statistical models borrowed from ecology.
Detailed description
In the thymus of an animal model of type I diabetes, the population of regulatory T cells expresses a repertoire of antigen receptors that is approximately ten-fold less diverse than that found in mice resistant to autoimmune pathology. Genetic models later showed that this reduced diversity was involved in the susceptibility to diabetes. Researchers study the diversity of the TCR expressed by regulatory T cells from paediatric type I diabetes patients and controls. Regulatory T cells emigrated from the thymus will be isolated from the blood of patients and healthy controls. The repertoire of antigen-receptors will be analysed by high throughput sequencing and its diversity estimated using appropriate statistical models borrowed from ecology.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Blood collection | Ten cc of peripheral blood will be taken from patients and healthy controls as soon as possible after T1D diagnosis of the former. |
Timeline
- Start date
- 2018-03-01
- Primary completion
- 2019-03-01
- Completion
- 2019-03-01
- First posted
- 2017-08-02
- Last updated
- 2020-04-01
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT03236558. Inclusion in this directory is not an endorsement.