NCT03236441

Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury

Biochemical and Reno-protective Effects of Remote Ischemic Pre-conditioning on Contrast-induced Acute Kidney Injury

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 110 (actual)
• Sponsor: Oladipupo Olafiranye, MD, MS · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This a prospective, double-blind, sham-controlled, randomized clinical trial to study the effects of remote ischemic preconditioning on acute kidney injury, vascular and renal biomarkers in patients with non-ST elevation myocardial infarction and unstable angina undergoing coronary angiography and/or percutaneous coronary intervention.

Detailed description

The BRICK study is a prospective, double-blind, sham-controlled, randomized clinical trial in patients with non-ST elevation myocardial infarction and unstable angina undergoing coronary angiography and/or percutaneous coronary intervention who are at high risk for acute kidney injury. The study will investigate the effects of remote ischemic preconditioning before cardiac catheterization on rate of acute kidney injury and novel biomarkers of renal injury/protection within 48hrs of coronary angiography and/or percutaneous coronary intervention.

Conditions

• Contrast-induced Acute Kidney Injury

Interventions

Type	Name	Description
DEVICE	RIPC	Remote ischemic preconditioning
DEVICE	Sham-RIPC	Control

Timeline

• Start date: 2018-03-06
• Primary completion: 2023-02-28
• Completion: 2024-02-28
• First posted: 2017-08-02
• Last updated: 2025-01-09
• Results posted: 2025-01-09

Locations

2 sites across 1 country: United States

Regulatory

• FDA-regulated device study