NCT03235635

Metagenomic Analysis of Gut Microbiome in Preterm

Metagenome Analysis of Intestinal Microbiome in Mortality and Morbidity of Preterm Infants

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 120 (estimated)
• Sponsor: Wonju Severance Christian Hospital · Academic / Other
• Sex: All
• Age: 1 Day – 1 Day
• Healthy volunteers: Not accepted

Summary

This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and morbidity, mortality.

Detailed description

Microbiome is the collection of all the microorganisms living in association with the human body which are consist of eukaryotes, archaea, bacteria and viruses. Microbiome in an average human body number are ten times more than human cells and have about 1000 more genes than are present in the human genome. There are symbiotic relationships between human and microbiome. If investigators are able to know about relationships between newborn and intestinal microbiome, mortality and morbidity in preterm infants may be improved. The investigators will collect the first and weekly stool of participants and analyze DNA of microbiome thorough Metagenomic anlysis. The results between 3 groups(preterm, late preterm and full-term infants) will be compared. The investigators expect that a mean distribution of intestinal microbiome in newborns(preterm, late preterm and full-term) is defined and that relationships between mortality, morbidity and intestinal microbiome.

Conditions

• Microbial Colonization
• Microbial Superinvasion
• Microbial Substitution
• Newborn Morbidity

Timeline

• Start date: 2017-07-25
• Primary completion: 2019-02-28
• Completion: 2019-02-28
• First posted: 2017-08-01
• Last updated: 2017-08-01

Locations

1 site across 1 country: South Korea