NCT03234205

Measurements of Myocardial Relaxation Time by MRI During Respiration

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 9 (actual)
• Sponsor: Central Hospital, Nancy, France · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Measurement of T2 transversal relaxation time by magnetic resonance has a major interest in cardiac imagery. It has been initially used for quantitative evaluation of heart viability and more recently for edema characterization. It allows to prematurely detect a cardiac transplant rejection. This technique needs successively around ten FSE sequences during apnea. Weak reproducibility of successive apneas and discomfort of patient limit the precision of this measurement and consequently its use in standard care. The ARTEMIS study method allows the examination during free respiration without prolonging the duration of examination compared to the examination during apnea. Moreover, image processing is simplified and correction of respiratory movements renders results more reliable. This is a pilot study of evaluation of ARTEMIS technique of image reconstruction. ARTEMIS is a method of MRI image reconstruction for measurements of T2 transversal relaxation. It allows to obtain diagnostic images without movement artifacts. The primary objective si to show the feasibility of ARTEMIS method for measurement of myocardial T2 relaxation time during free respiration in cardiac transplant patients. The secondary objective is to collect quantitative data to compare ARTEMIS method of measurement of T2 during free respiration and standard clinical practice during apnea.

Conditions

• Heart Transplantation

Interventions

Type	Name	Description
DEVICE	MRI scan	MRI standard protocol with addition of: * a second clinical respiratory belt besides belt usually installed for clinical examination * a second clinical electrocardiogram sensor besides sensor usually installed for clinical examination * 12 sequences during free respiration are added lasting supplementary 15 minutes * Use of cardiac antennae usually used for cardiac MRI scans

Timeline

• Start date: 2011-08-31
• Primary completion: 2012-12-19
• Completion: 2012-12-19
• First posted: 2017-07-31
• Last updated: 2017-08-03

Locations

1 site across 1 country: France