NCT03233568

Use of Indirect Calorimetry in Obesity

Use of Indirect Calorimetry in Dietary Setting in Obese Subjects: Retrospective Observational Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 355 (actual)
• Sponsor: Ospedale San Donato · Academic / Other
• Sex: All
• Age: 20 Years – 86 Years
• Healthy volunteers: Not accepted

Summary

The investigators will retrospectively analyze and compare data of 2 groups of overweight and obese patients: subjects who followed a diet based on Resting Energy Expenditure (REE) measured by indirect calorimetry and subjects who followed a diet based on REE estimated by the Harris-Benedict equation. Propensity score adjustment will be used to adjust for known differences between the 2 groups

Conditions

• Metabolism Disorder
• Overweight and Obesity

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Indirect calorimetry	Indirect calorimetry will be performed by using an open-circuit calorimeter (Sensor Medics, Italy). Indirect calorimetry is the reference method for energy expenditure determination. A canopy hood covered the patient's head and expired air is extracted by a pump to be analyzed by metabolic cart sensors; flow rate is directly measured with a digital turbine flowmeter. After an overnight fast, patients will asked to lay supine in complete physical rest, not sleeping or talking for approximately 20-25 minutes, at a room temperature ranged between 22 and 24°C. The mean REE for each participant considers the last 15-20 minutes of measurements corresponding to steady state. Software of calorimeter will be set for minute-by-minute reading report of VO2 (Oxygen flow) and VCO2 (Carbon dioxide flow) measurement. Parameters obtained by Indirect Calorimetry will be the Resting Energy Expenditure and the Respiratory Quotient (RQ)

Timeline

• Start date: 2012-04-01
• Primary completion: 2016-10-31
• Completion: 2016-10-31
• First posted: 2017-07-28
• Last updated: 2017-07-28

Locations

1 site across 1 country: Italy