NCT03233399

Modulating Movement Intention Via Cortical Stimulation

Modulating Movement Intention Via Cortical Stimulation in Healthy Subjects and Patients With Psychogenic Movement Disorders and Non-epileptic Seizures

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: NYU Langone Health · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.

Detailed description

This study will: * Explore effects of TMS and tDCS on movement intention. * Discern the neural activity underlying modulation of movement intention with neuroimaging recording. * Identify brain stimulation's effect in patients with psychogenic tremor and non-epileptic seizures. * Technical development of new experimental paradigms and data analysis methods. * Data collection for hypotheses development.

Conditions

• Seizures
• Seizure Disorder
• Psychogenic Movement Disorder

Interventions

Type	Name	Description
DEVICE	Sham TMS3 stimulation	half of the subjects will receive sham stimulation first
DEVICE	rTMS of left or right angular gyrus (AG) or frontal cortex (FC)	Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study.
DEVICE	Anodal tDCS of left or right AG or FC	Half of the subjects will receive active stimulation first; A subject may receive either TMS or tDCS stimulation, but not both, over the course of the sub-study.

Timeline

• Start date: 2017-07-20
• Primary completion: 2027-05-01
• Completion: 2027-05-01
• First posted: 2017-07-28
• Last updated: 2025-11-28

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study