NCT03232957

Intrathecal Morphine for Unilateral Total Knee Arthroplasty

Efficacy and Side Effects of Intrathecal Morphine in Multimodal Analgesia for Unilateral Total Knee Arthroplasty

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 131 (actual)
• Sponsor: Mahidol University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

This study evaluates postoperative numerical pain score and systemic opioid requirement within 48 hours for unilateral total knee arthroplasty. Comparing among 3 groups of intrathecal morphine; 0,50, 100 ug with multimodal analgesia.

Detailed description

Intrathecal opioid is effective postoperative analgesia for orthopedic lower extremity surgery. However there are some limitations such as nausea, vomiting, pruritus, dizziness. Nowadays multimodal analgesia is used in unilateral total knee arthroplasty include oral analgesic drugs, adductor canal block and local analgesia infiltration. This study evaluates whether intrathecal opioid should be added in the role of multimodal analgesia in total knee arthroplasty.

Conditions

• Primary Osteoarthritis of Knee Nos

Interventions

Type	Name	Description
PROCEDURE	50 ug IT morphine	Spinal block with bupivacaine and intrathecal morphine 50 ug
PROCEDURE	100 ug IT morphine	Spinal block with bupivacaine and intrathecal morphine 100 ug
PROCEDURE	No IT morphine	Spinal block with bupivacaine and intrathecal morphine 0 ug
DRUG	Morphine	intrathecal morphine
DRUG	Bupivacaine	0.5 isobaric bupivacaine

Timeline

• Start date: 2017-08-01
• Primary completion: 2019-02-01
• Completion: 2019-07-31
• First posted: 2017-07-28
• Last updated: 2021-05-24

Locations

1 site across 1 country: Thailand