NCT03232034

Calcium, Protein and Gut Hormones

The Role of Dietary Milk Minerals and Protein in Gut Hormone Secretion

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: University of Bath · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Gut hormones have therapeutic potential in the prevention and treatment obesity and type 2 diabetes (T2D). Milk protein and calcium can each potentiate gut hormones following meal ingestion in humans. However, these nutrients may interact synergistically (and with other minerals in milk) such that specific co-ingestion of these nutrients is required to obtain the full therapeutic potential for metabolism and energy balance. This proposal is to perform a pilot study on the effect of co-ingesting Capolac® plus protein on circulating gut hormone responses.

Detailed description

Participants will be asked to arrive to the laboratory between 08:00 and 10:00 am after not eating for between 8-14 hours i.e. in a fasted state (water intake is permitted and encouraged). Participants will then be given one of three test drinks: 1) calcium citrate (1000 mg); 2) milk mineral supplement (equating to 1000 mg calcium); or 3) milk mineral supplement (equating to 1000 mg calcium) plus whey protein hydrolysate (50 g). Each of these drinks will also contain 500 mL of water and artificial sweetener (80 mg sucralose). Blood samples will be taken before, and at 15, 30, 45, 60, 90 and 120 minutes after ingestion of the test drink to determine the concentrations of gut hormones (GIP, GLP-1 and PYY) circulating in the bloodstream. We will also ask participants to complete an appetite questionnaire at baseline and every 30 minutes after ingestion of the test drink to assess their appetite sensations. After the 120-minute time point, we will remove the cannula and the trial day will be complete.

Conditions

• Obesity
• Diabetes

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Calcium Citrate	1000 mg calcium as calcium citrate
DIETARY_SUPPLEMENT	Milk Mineral Supplement	Milk Minerals containing 1000 mg calcium
DIETARY_SUPPLEMENT	Whey Protein Hydrolysate	50 g whey protein hydrolysate

Timeline

• Start date: 2017-05-01
• Primary completion: 2017-12-05
• Completion: 2018-01-31
• First posted: 2017-07-27
• Last updated: 2018-08-28

Locations

1 site across 1 country: United Kingdom