NCT03230188

Patterns of Neurocircuitry Activation In Severe Asthma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 28 (actual)
• Sponsor: University of Wisconsin, Madison · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The overall purpose of the study is to compare the patterns of neurocircuitry activation in severe asthmatics vs. mild to moderate and healthy controls. The Investigators hypothesize that neurocircuitry activation increases with asthma severity, producing different neurocircuitry patterns for severe asthmatics than those of mild to moderate asthmatics or non-asthmatics.

Detailed description

To begin to further address possible relationships of asthma and brain function, the investigators propose the following hypothesis, "patients with defined characteristics of severe asthma will have distinct patterns of persistent neurocircuitry activation. The investigators further propose that the detection of ongoing neurocircuitry activation occurs because of persistent and active airway inflammation in severe asthma. Finally, the investigators propose that the intensity of specific neurocircuitry activation will relate to the severity of underlying asthma.

Conditions

• Lung Diseases

Interventions

Type	Name	Description
OTHER	functional Magnetic Resonance Imaging (research grade)	Subjects will undergo a simulated and actual functional Magnetic Resonance Imaging scan.
OTHER	Cognitive Function Testing (non-diagnostic)	Subjects will take non-diagnostic cognitive function tests
OTHER	Asthma and Psychological Questionnaires (non-diagnostic)	Subjects will fill out asthma and psychological questionnaires (non-diagnostic)

Timeline

• Start date: 2017-08-01
• Primary completion: 2018-06-17
• Completion: 2018-06-17
• First posted: 2017-07-26
• Last updated: 2019-01-24

Locations

1 site across 1 country: United States