NCT03228069

Immune Responses and Immunological Tolerance After Rabies Booster Vaccination in HIV-infected Adults

Humoral and Cell-mediated Immune Responses and Immunological Tolerance After Rabies Booster Vaccination in Previously Rabies Immunized HIV-infected Adults

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Queen Saovabha Memorial Institute · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

To study the humoral and cell-mediated immune responses in HIV-infected adults who had previously received rabies booster vaccination more than a year before

Detailed description

Previous study has shown the higher immunogenicity response among HIV-infected adults who received a single visit 4-site intradermal rabies booster vaccination than those who received the conventional intramuscular regimen. The investigators follow the persistence of these effects. Also, the regulatory T cell levels were examined after the rabies booster vaccination .

Conditions

• Rabies

Interventions

Type	Name	Description
PROCEDURE	Blood drawn after rabies booster vaccination	Blood would be drawn for testing of rabies neutralizing antibody titers, rabies specific T lymphocytes and regulatory T cells after receipt of rabies booster vaccination at least a year before.

Timeline

• Start date: 2017-08-01
• Primary completion: 2023-12-01
• Completion: 2023-12-01
• First posted: 2017-07-24
• Last updated: 2022-04-29

Locations

1 site across 1 country: Thailand