NCT03227900

Lidocaine and Food Intake

The Effect of lidocaïne Infusion on ad Libitum Food Intake and Satiety in Healthy Volunteers

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: Male
• Age: 18 Years – 50 Years
• Healthy volunteers: Accepted

Summary

World's population over 60 years old is increasing rapidly. It is expected that in 2050 elderly population will be 22% of the total population, representing around 2 billion people. This situation means a rising in the incidence of elderly-related diseases, and thereby the need for long-term care. Reduction in body fat and weight are a common problem among the institutionalized elderly. Some factors that contribute to the anorexia of aging are decreased perception of hunger and increased satiation. This represents an increased risk of developing cachexia even during minor illnesses. The potentially severe consequences of anorexia of aging a greater understanding of the underlying mechanism of these changes is highly important. Intraesophageal and intragastric infusion of 20mg/kg lidocaine results in an increase in food intake in Wistar rats. All infusions were done 30 minutes before the start of the meal intake (meal consisted of mealworms). It may be possible to decrease satiation, increase hunger, and hence food intake in elderly individuals through gastric infusion of the anesthetics lidocaine or benzocaine. In the future this study could potentially contribute to improve food intake in elderly vulnerable of losing body weight. Therefore, the current study aims to investigate the effect of intragastric administration of lidocaine on food intake, satiety/satiation and gastrointestinal complaints.

Detailed description

Aim: To determine the effect of intragastric infusion of lidocaine on satiation, gastrointestinal complaints and food intake. Hypothesis: We hypothesize that intragastric administration of lidocaine will result in a delay of postprandial satiation and hereby will result in an increase in food intake. Furthermore, lidocaine infusion will not result in an increase in any gastrointestinal complaints. Primary objective: To investigate the effect of intragastric infusion of lidocaine on ad libitum food intake. Secondary Objective(s): 1. To investigate the effect of intragastric infusion of lidocaine on satiety/satiation. 2. To study the effect of intragastric infusion of lidocaine on gastrointestinal complaints. Design: Double blind randomized placebo-controlled cross-over trial in healthy male volunteers. Study population: 35 healthy human male volunteers, 18 - 50 years old. Main study parameters/endpoints: Difference in ad libitum meal intake (as measured during ad libitum chili con carne meal). Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Visual Analogue Scales (VAS) scores for satiety feelings (e.g., satiety, fullness, hunger, prospective feeding, desire to eat, desire to snack) and gastrointestinal symptoms (burning, bloating, belching, cramps, colics, warm sensation, sensation of abdominal fullness, nausea and pain) will be measured using VAS (0 to 100 mm) anchored at the low end with the most negative or lowest intensity feelings (e.g., extremely unpleasant, not at all), and with opposing terms at the high end (e.g., extremely pleasant, very high, extreme). Volunteers will be asked to indicate on a line which place on the scale best reflects their feeling at that moment. The scoring forms will be collected immediately so that they cannot be used as a reference for later scorings. Catheter placement: the subjects will perceive mild discomfort during the placement of the catheter. Subjects can, at any time, come in contact with the investigator if any problems occur. All participants are healthy volunteers and we don't expect any health benefits or disadvantages.

Conditions

• Hunger

Interventions

Type	Name	Description
DRUG	Lidocaine	Intragastric infusion of lidocain
DRUG	Placebos	Intragastric infusion of water for injections

Timeline

• Start date: 2017-07-19
• Primary completion: 2018-06-26
• Completion: 2018-06-26
• First posted: 2017-07-24
• Last updated: 2018-08-01

Locations

1 site across 1 country: Netherlands