NCT03227458

DHEA Augmentation of Musculoskeletal Adaptations to Exercise in Older Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 152 (actual)
• Sponsor: University of Colorado, Denver · Academic / Other
• Sex: Female
• Age: 55 Years – 85 Years
• Healthy volunteers: Accepted

Summary

To determine whether the musculoskeletal adaptations to bone-loading exercise can be significantly augmented in older women (aged 60-85) with low bone mass (osteopenia; T-scores \<-1.0 and \>-2.5) or moderate osteoporosis (T-scores \< -2.5 and \>= -3.0) and by restoring serum DHEAS to young adult levels by oral DHEA replacement.

Detailed description

This will be the first study to measure changes in areal bone mineral density (aBMD) and fat-free mass (FFM) in response to dehydroepiandrosterone (DHEA) alone and combined with exercise in postmenopausal women. The body of evidence from carefully executed Randomized Controlled Studies (RCTs) provides support for DHEA therapy to increase aBMD and FFM in older women. Less is known about whether DHEA therapy enhances the effects of exercise on the aging musculoskeletal system when an appropriate mechanical stimulus is applied.

Conditions

• Low Bone Mass
• Osteoporosis, Postmenopausal

Interventions

Type	Name	Description
OTHER	DHEA	Participants will take 1 study pill (50 mg DHEA) daily for 36 weeks.
OTHER	Placebo	Participants will take placebo daily for 36 weeks.
BEHAVIORAL	Exercise	bone-loading exercise on 3 days per week for 38 weeks

Timeline

• Start date: 2018-02-12
• Primary completion: 2024-06-19
• Completion: 2024-06-19
• First posted: 2017-07-24
• Last updated: 2024-12-05

Locations

1 site across 1 country: United States