NCT03225378

Changes in PPV Induced by PLR Test to Predict Fluid Responsiveness in ICU

Changes in Pulse Pressure Variations Induced by Passive Leg Raising Test to Predict Fluid Responsiveness in ICU

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 286 (actual)
• Sponsor: Centre Hospitalier Arras · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The passive leg raising (PLR) test is a reversible preload challenge of around 300 mL of blood that can be repeated as frequently as required without infusing a drop of fluid. Two recent meta-analyses of many studies have confirmed the reliability of the PLR test to predict fluid responsiveness in patients with acute circulatory failure. Nevertheless, the effects of the PLR must be assessed by the direct measurement of cardiac output since changes in arterial pressure do not allow the assessment of the PLR hemodynamic effects with reliability. Moreover, cardiac output must be measured continuously and in real time. In clinical practice, cardiac output measurement can be difficult for different reasons such as the unavailability of the echocardiography machine, or the absence of any continuous cardiac output monitoring technique at the time of acute circulatory failure occurrence. Recently, it was shown that the decrease in pulse pressure variation (PPV) induced by the mini-fluid challenge (100 mL of colloid solution infused in 1 min) was able to predict fluid responsiveness with reliability in patients ventilated with low tidal volume (\<8 mL/kg of ideal body weight). Therefore, the investigators hypothesize that the changes in PPV induced by PLR test could be able to predict fluid responsiveness with reliability in mechanically ventilated patients with acute circulatory failure.

Conditions

• Acute Circulatory Failure

Interventions

Type	Name	Description
OTHER	Fluid loading of 500 mL of crystalloid solution	Infusion of 500 mL of crystalloid solution in less than 15 minutes
OTHER	Passive Leg Raising test	This intervention is done before the fluid loading in order to predict fluid responsiveness.

Timeline

• Start date: 2017-09-21
• Primary completion: 2021-09-20
• Completion: 2021-09-20
• First posted: 2017-07-21
• Last updated: 2021-10-27

Locations

12 sites across 1 country: France