NCT03222011

Stricture Definition and Treatment (STRIDENT) Endoscopic Therapy Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: St Vincent's Hospital Melbourne · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Two thirds of patients with Crohn's disease require intestinal surgery at some time in their life. Intestinal strictures, that is narrowing of the bowel due to inflammation and scarring, are the most common reason for surgery. Despite the high frequency, associated disability, and cost there are no are no treatment strategies that aim to improve the outcome of this disease complication. The STRIDENT (stricture definition and treatment) studies aim to develop such strategies.

Detailed description

Prospective randomised controlled study. Patients with Crohn's Disease and symptomatic stricture(s) will undergo randomisation to receive standard or intensive endoscopic therapy.

Conditions

• Crohn Disease
• Inflammatory Bowel Diseases
• Stricture; Bowel

Interventions

Type	Name	Description
PROCEDURE	Standard (single) endoscopic stricture dilatation	single endoscopic stricture dilatation
PROCEDURE	Intensive endoscopic stricture dilatation	3 endoscopic dilatations 3 weeks apart and possible needle knife strictureplasty

Timeline

• Start date: 2017-10-09
• Primary completion: 2021-02-01
• Completion: 2021-02-01
• First posted: 2017-07-19
• Last updated: 2020-10-23

Locations

1 site across 1 country: Australia