NCT03220542

The Effect of Broccoli Sprout Extract and Probiotics for Eradication of Helicobacter Pylori

The Effect of Broccoli Sprout Extract and Probiotics on Proton Pump Inhibitor-based Triple Therapy for Eradication of Helicobacter Pylori: a Prospective Randomized Trial

• Status: Unknown
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 360 (estimated)
• Sponsor: Kyunghee University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

In Korea, the first-line therapy to treat Helicobacter pylori (Hp) consists of a proton pump inhibitor (PPI) and two antibiotics for one week. But, eradication has become less successful due to low compliance and high resistance to the antibiotics. Therefore, it is necessary to develop new treatment strategies that increase the eradication rate and reduce adverse effects. In vitro study, we previously reported that a broccoli sprout extract containing sulforaphane may prevent lipid peroxidation in the gastric mucosa and play a cytoprotective role in Hp-induced gastritis. Also, several studies suggested that probiotics could be effective for improving Hp eradication rate or reducing adverse events. But, their effect for eradication of Hp is not yet conclusive. The aims of this prospective study is to investigate the efficacy of a broccoli sprout extract containing sulforaphane and probiotics for eradication of Hp, compared with standard triple therapy.

Conditions

• Helicobacter Pylori Infection

Interventions

Type	Name	Description
DRUG	Probiotics	Saccharomyces boulardii
DIETARY_SUPPLEMENT	Broccoli	Broccoli sprouts extract
DRUG	Esomeprazole	Esomeprazole
DRUG	Amoxicillin	Amoxicillin
DRUG	Clarithromycin	Clarithromycin

Timeline

• Start date: 2016-01-01
• Primary completion: 2018-12-31
• Completion: 2019-12-31
• First posted: 2017-07-18
• Last updated: 2019-06-04

Locations

1 site across 1 country: South Korea