NCT03218579

Endoscopic Assessment and Prediction of Microbiome-modifying Interventions

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Tel-Aviv Sourasky Medical Center · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

The investigators would like to examine the extent of gut microbiome rehabilitation in healthy people after the consumption of antibiotics. Outcomes of probiotic treatment versus bacteriotherapy will be compared.

Detailed description

The investigators would like to examine the extent of rehabilitation of the composition and functioning of the intestinal bacteria in healthy people after the consumption of antibiotics. Since the digestive mocus enables the connection between the host and the bacteria that live within it, the investigators would like to characterize the microbiome in the different areas along the digestive system - before antibiotic treatment and after rehabilitation by probiotic treatment versus bacteriotherapy.

Conditions

• Gut Microbiome
• Antibiotic Side Effect

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Probiotic treatment	4 weeks of probiotic treatment after 7 days of antibiotics (Metronidazole+Ciprofloxacin)
BIOLOGICAL	Bacteriotherapy	Bacteriotherapy (autologous fecal microbiota transplantation) after 7 days of antibiotics (Metronidazole+Ciprofloxacin)

Timeline

• Start date: 2013-02-01
• Primary completion: 2019-12-30
• Completion: 2020-12-30
• First posted: 2017-07-14
• Last updated: 2017-07-21

Locations

1 site across 1 country: Israel