NCT03218124

Optimal Remifentanil Concentration and Thyroidectomy

Optimal Effect Site Remifentanil Concentration for Smooth Extubation After Thyroid Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: University of Cagliari · Academic / Other
• Sex: All
• Age: 18 Years – 67 Years
• Healthy volunteers: Not accepted

Summary

The study is aimed at determining the remifentanil effect site concentration suppressing the cough at extubation after surgical thyroidectomy, performed under remifentanil/desflurane based general anesthesia, expressed as median and 95th percentile effective dose. Possible hemodynamic instability, respiratory depression or prolongation of awakening time are also sought.

Conditions

• Anesthesia

Interventions

Type	Name	Description
OTHER	Remifentanil Effect site concentration	After skin suture, a predetermined Effect site remifentanil concentration will be achieved. Starting from 1.5 ng/ml in the first patient and increased or decreased by 0.2 ng/ml intervals based on the previous patient response: up if cough present, down otherwise ("Dixon's up and down" method).

Timeline

• Start date: 2017-10-01
• Primary completion: 2018-06-01
• Completion: 2018-07-01
• First posted: 2017-07-14
• Last updated: 2017-07-14

Locations

1 site across 1 country: Italy