NCT03217500

Corneal Epithelial Autograft for Pterygium

A Randomized Controlled Clinical Trial of Corneal Epithelial Autograft for Pterygium

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Chunxiao Wang · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to explore whether femtosecond laser-assisted cornea epithelial autograft is more effective than limbal conjunctival autograft for ocular surface reconstruction after excision of pterygium.

Conditions

• Pterygium

Interventions

Type	Name	Description
PROCEDURE	Corneal epithelial autograft	After removal of the recipient's pterygium tissue, a donor epithelial tissue equal in length to the bared limbus, will be obtained from the peripheral epithelial of the same eye (corneal epithelial autograft) using femtosecond laser technology. The epithelial graft will be sutured to the recipient limbal bed, with the goal of reconstruction of palisades of Vogt. The graft will act as a barrier to regrowth of pterygium. The area of the graft will be left with the Tenon capsule exposed.
PROCEDURE	Limbal conjunctival autograft	After removal of the recipient's pterygium tissue, an adjustable diamond knife will be used to create a superficial circumferential incision at the corneal end of the limbal vascular arcade, equal in length to the bared limbus. This will be followed by harvesting the limbal-conjunctival flap. The limbal-conjunctival autograft will be sutured to the recipient bed, with the Tenon capsule exposed. The graft will serve as a barrier to regrowth of pterygium.
PROCEDURE	Simple removal	Simple removal of the recipient's pterygium tissue, with the Tenon capsule exposed.
DEVICE	Diamond knife	A diamond knife to create a particular shaped limbal graft for transplantation
DEVICE	Femtosecond laser	A commercial femtosecond laser to create a particular shaped graft for transplantation

Timeline

• Start date: 2017-07-20
• Primary completion: 2018-12-30
• Completion: 2019-12-30
• First posted: 2017-07-14
• Last updated: 2018-02-22

Locations

1 site across 1 country: China