NCT03217487

Corneal Epithelial Autograft for LSCD

A Randomized Controlled Clinical Trial of Corneal Epithelial Autograft for the Treatment of Limbal Stem Cell Deficiency

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Chunxiao Wang · Academic / Other
• Sex: All
• Age: 14 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial autograft is more effective than limbal conjunctival autograft for ocular surface reconstruction in patients with limbal stem cell deficiency (LSCD).

Conditions

• Limbal Stem Cell Deficiency

Interventions

Type	Name	Description
PROCEDURE	Corneal epithelial autograft	Epithelial tissue, equal in area to the diseased eye's cornea bed, will be obtained from the fellow eye using femtosecond laser technology. This corneal epithelial autograft is then ready for transplantation on the disease eye, following removal of scarred and diseased epithelium.
PROCEDURE	Limbal conjunctival autograft	A 3- to 5- clock hour limbal-conjunctival autograft will be obtained from the fellow eye. This is then ready for transplantation on the disease eye following removal of scarred and diseased epithelium.
DEVICE	Femtosecond laser	A commercial femtosecond laser to create a particular shaped graft for transplantation
DEVICE	Diamond knife	A diamond knife to create a particular shaped limbal graft for transplantation

Timeline

• Start date: 2017-07-25
• Primary completion: 2019-10-30
• Completion: 2019-12-30
• First posted: 2017-07-14
• Last updated: 2019-08-09

Locations

1 site across 1 country: China