NCT03217435

Corneal Epithelial Allograft From Living-related Donor for LSCD

A Non-randomized Controlled Clinical Trial of Epithelial Allograft Transplantation From Living-related Donors for the Treatment of Limbal Stem Cell Deficiency

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Chunxiao Wang · Academic / Other
• Sex: All
• Age: 14 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The purpose of the study is to explore whether femtosecond laser-assisted corneal epithelial allograft from living-related donor is more effective than limbal conjunctival allograft from living-related donor for ocular surface reconstruction in patients with limbal stem cell deficiency (LSCD).

Conditions

• Limbal Stem Cell Deficiency

Interventions

Type	Name	Description
PROCEDURE	Corneal epithelial allograft	A living-related donor's epithelial flap, equal in area to the recipient's diseased cornea bed, will be created using femtosecond laser technology. This corneal epithelial allograft is then ready for transplantation on the recipient's disease eye, following removal of the recipient's scarred and diseased epithelium.
PROCEDURE	Limbal conjunctival allograft	A 3- to 5- clock hour limbal-conjunctival allograft will be obtained from the living-related eye. This is then ready for transplantation on the recipient's disease eye following removal of the recipient's scarred and diseased epithelium.
DEVICE	Femtosecond laser	A commercial femtosecond laser to create a particular shaped graft for transplantation
DEVICE	Diamond knife	A diamond knife to create a particular shaped limbal graft for transplantation

Timeline

• Start date: 2017-07-27
• Primary completion: 2019-11-13
• Completion: 2019-11-13
• First posted: 2017-07-14
• Last updated: 2020-02-28

Locations

1 site across 1 country: China