NCT03213288

Bilberry Fruit and Black Rice Derived Anthocyanins on Lipid Status

The Effects of Bilberry Fruit and Black Rice Derived Anthocyanins on Lipid Status in Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 55 (actual)
• Sponsor: Quadram Institute Bioscience · Academic / Other
• Sex: All
• Age: 45 Years
• Healthy volunteers: Accepted

Summary

The primary aim of this study is to directly compare the two major types of anthocyanins found in the diet (cyanidin-type and delphinidin-type) on lipid status in adults.

Detailed description

Human intervention trials with anthocyanin-rich berry fruits/extracts such as whole strawberries, elderberry juice and whortleberry extracts, and purified anthocyanins from a mixture of blackcurrant and bilberry have been shown to beneficially alter biological markers for CVD risk, with beneficial effects on lipid profiles common across these studies. In a randomized 3 phase crossover study we aim to recruit 50 participants (men and women) aged 45 years or more with a higher than optimal blood cholesterol level to consume capsules containing (i) 320 mg anthocyanins derived from bilberry fruit (delphinidin type), (ii) 320 mg anthocyanins derived from black rice (cyanidin type) and (iii) a placebo control. Each treatment will be ingested for 28 days with a wash-out period of 4 weeks in-between. Blood samples will be collected at the start and end of each 28-day treatment period to assess lipid status. In a subset of participants we will also investigate the relationship between bilberry and black rice anthocyanin ingestion on RNA expression profiles that are known to be involved in atherosclerosis, non-alcoholic fatty liver disease and reverse cholesterol transport as well as faecal excretion of bile acids and lipids.

Conditions

• Hyperlipidemia

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Delphinidin type anthocyanins	Bilberry extract containing Delphinidin type anthocyanins
DIETARY_SUPPLEMENT	Cyanidin type anthocyanins	Black rice extract containing Cyanidin type anthocyanins
DIETARY_SUPPLEMENT	Placebo	No anthocyanins

Timeline

• Start date: 2017-09-25
• Primary completion: 2018-09-30
• Completion: 2018-09-30
• First posted: 2017-07-11
• Last updated: 2019-12-10

Locations

1 site across 1 country: United Kingdom