NCT03211676

Comparison of Hemodialysis With Medium Cut-off Dialyzer (Theranova) and High Flux Dialyzer

Comparison of Hemodialysis With Medium Cut-off Dialyzer (Theranova) and High Flux Dialyzer on Removal of Small and Middle Size Molecules, Inflammatory Parameters and Oxidative Stress. An Open Cross Over Randomized Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 49 (actual)
• Sponsor: Poitiers University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the removal of midle molecules and inflammatory cytokines with the Theranova-500 ™ dialyzer (medium cut-off membrane, Baxter®) versus a high flux dialyzer Elisio-21H ™ (High-flux membrane, Nipro®) in chronic hemodialysis. Evaluation of nutritional parameters, inflamatory parameters and oxidative stress will also be carried out. Finally, the investigators will compare hepcidin levels and the erythropoietin resistance index between the two groups.

Conditions

• End Stage Renal Disease
• Dialysis Related Complication
• Dialysis Amyloidosis

Interventions

Type	Name	Description
DEVICE	Theranova-500 dialyzer	hemodialysis with Theranova-500 dialyzer.
DEVICE	Elisio-21H	hemodialysis with Elisio-21H dialyzer

Timeline

• Start date: 2017-06-07
• Primary completion: 2018-03-14
• Completion: 2018-06-14
• First posted: 2017-07-07
• Last updated: 2020-04-13

Locations

1 site across 1 country: France