NCT03211442

Implications of MEDIcal Low Dose RADiation Exposure - BReast Cancer Acute Coronary Events

Implications of MEDIcal Low Dose RADiation Exposure - BReast Cancer Acute Coronary Events (MEDIRAD-BRACE): A Retrospective Cohort Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 7,000 (actual)
• Sponsor: University Medical Center Groningen · Academic / Other
• Sex: Female
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

MEDIRAD-BRACE aims to determine the relationship between 3D dose distributions in cardiac structures and the risk of acute coronary events (ACE) and other cardiac complications in breast cancer (BC) patients to develop and externally validate multivariable Normal Tissue Complication Probability (NTCP) models to assess the risk of ACE in individual patients based on cardiac dose metrics in the first 10 years after BC radiotherapy.

Conditions

• Breast Cancer Female
• Acute Coronary Events
• Cardiac Complications

Interventions

Type	Name	Description
RADIATION	Radiotherapy	Breast cancer patients treated with radiotherapy

Timeline

• Start date: 2017-08-01
• Primary completion: 2020-08-01
• Completion: 2022-06-01
• First posted: 2017-07-07
• Last updated: 2024-02-28

Locations

1 site across 1 country: Netherlands