NCT03209193

Effect of Anesthetics on Microcirculation in Patients Undergoing Off-pump Coronary Artery Bypass Surgery

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 72 (actual)
• Sponsor: Seoul National University Hospital · Academic / Other
• Sex: All
• Age: 20 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

Volatile anesthetics, such as sevoflurane and desflurane, are commonly used in patients undergoing cardiac surgeries including off-pump coronary artery bypass. However, the effect of volatile anesthetics on microcirculation in patients undergoing off-pump coronary artery bypass has not been well conducted.

Detailed description

This is a prospective randomized clinical trial investigating the effect of sevoflurane vs. desflurane on tissue microcirculation in patients undergoing off-pump coronary artery bypass surgery. Eligible patients are going to be randomized to receive sevoflurane or desflurane, as a maintenance anesthetic, during the surgery. Tissue oxygen saturation and microcirculatory changes, such as an occlusion and recovery slope, during vascular occlusion test will be recorded during the surgery. The primary end point of the study is the difference in tissue oxygen saturation between the groups.

Conditions

• Microcirculation
• Anesthetic Complication Spinal

Interventions

Type	Name	Description
DRUG	Sevoflurane	Sevoflurane use as main anesthetic drug during the surgery
DRUG	Desflurane	Desflurane use as main anesthetic drug during the surgery

Timeline

• Start date: 2017-07-04
• Primary completion: 2019-11-07
• Completion: 2019-11-07
• First posted: 2017-07-06
• Last updated: 2020-03-04

Locations

1 site across 1 country: South Korea