NCT03208387

Understanding the Late Effects of Surviving a Pediatric Brain Tumor

Biological Substrates of Impaired Neurocognitive Functioning: Understanding the Late Effects of Surviving a Pediatric Brain Tumor

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 42 (actual)
• Sponsor: Memorial Sloan Kettering Cancer Center · Academic / Other
• Sex: All
• Age: 6 Years – 16 Years
• Healthy volunteers: —

Summary

The goal of this study is to learn about the cognitive and behavioral functioning of children being treated for cancer.

Conditions

• Brain Tumor
• Pediatric Brain Tumor
• Pediatric Cancer

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Diffusion tensor imaging (DTI)	DTI quantifies the degree to which water diffuses in different directions through a given brain region. The use of DTI as an in vivo index of the integrity of white matter has been applied to many disease states using several proprietary and open-source software programs (e.g. FSL 5.0). DTI tractography, employed via toolboxes such as Probtrackx within the FSL 5.0, allows the identification of white matter tracts connecting cortical and subcortical regions of interest. Furthermore, structural connectivity as measured with DTI does not duplicate functional connectivity as measure with rs-fcMRI, but rather provides complimentary perspectives.
DIAGNOSTIC_TEST	Resting state functional connectivity MRI (rs-fcMRI)	rs-fcMRI is a relatively new neuroimaging technique that has been applied to studying multiple clinical populations including ADHD, schizophrenia, major depressive disorder, and other neurological disorders. The approach exploits measurement of changes in brain blood oxygenation (BOLD) as is employed in task based functional MRI (measuring changes in focal cortical vascular oxygenation when engaged in a defined task, e.g. motor movement). Neuroimaging data will be collected as soon as possible (can be the same day), for up to 6 weeks.
BEHAVIORAL	Wechsler Intelligence Scale for Children - 5th edition (WISC-V)	Will gather IQ data and is the gold standard for IQ assessment for those between the ages of 6:0 and 16:11 years.
BEHAVIORAL	California Verbal Learning Test (CVLT-C)	Validated measure of verbal learning and memory for those between the ages of 5:0 and 16:11.
BEHAVIORAL	Beery Test of Visual Motor Integration 6th edition	Measure designed to assess visual-motor functioning of subjects between the ages of 2-99 years old by copying designs using paper and pencil.
BEHAVIORAL	Grooved Pegboard	This is a standard assessment of fine motor functioning and dexterity by asking the subject to place metal pegs into holes on a board.
BEHAVIORAL	PedsQL Multidimensional Fatigue Scale	Designed to measure fatigue in pediatric patients (ages 5-17 years) and is comprised of the General Fatigue Scale (6 items), Sleep/Rest Fatigue Scale (6 items) and Cognitive Fatigue Scale (6 items).
DIAGNOSTIC_TEST	MRI	Images will be acquired on a 3.0 Tesla MRI scanner at each of the four study sites. At MSK, resting state fMRI data will be obtained using a 3T GE scanner with an 8-channel head coil (Discovery 750w DV25)

Timeline

• Start date: 2017-06-28
• Primary completion: 2026-06-01
• Completion: 2026-06-01
• First posted: 2017-07-05
• Last updated: 2025-09-12

Locations

4 sites across 1 country: United States