NCT03204591

Bacterial Infections in Cirrhotic Patients With Acute Severe Liver Injury

Risk of Bacterial Infection in Cirrhotic Patients With Acute Severe Liver Injury: a Multicenter,Prospective, Observational Study

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 500 (estimated)
• Sponsor: The Zhejiang Study Group for Organ Failure in Cirrhosis · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Acute hepatic insults including hepatitis flare-up, active alcohol assumption and hepatotoxic drug use are common in patients with cirrhosis especially in Eastern countries.These patients are at high risk of developing acute-on-chronic liver failure (ACLF) and associated with high short-term mortality. And the natural history of these patients is frequently complicated by bacterial infections, which lead to deterioration of underlying diseases. The present study is aimed to investigate the prevalance and risk factors of bacterial infections in those patients and its impact on in-hospital/short-term mortality.

Conditions

• Cirrhosis, Liver
• Bacterial Infections
• Acute Liver Injury

Interventions

Type	Name	Description
OTHER	No intervention	No intervention

Timeline

• Start date: 2017-07-20
• Primary completion: 2018-10-18
• Completion: 2019-01-18
• First posted: 2017-07-02
• Last updated: 2018-06-06

Locations

1 site across 1 country: China