NCT03204461

Glucose Metabolism in Different PCOS Phenotypes

Associatons of PCOS Phenotypes With Ectopic Lipids, Adipocytokines and Parameters of Insulin Resistance

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 73 (actual)
• Sponsor: Medical University of Vienna · Academic / Other
• Sex: Female
• Age: 20 Years – 40 Years
• Healthy volunteers: Accepted

Summary

In the present study glucose metabolism and ectopic lipids in the liver, heart and muscle were investigated in women with the polycystic ovary syndrome (PCOS) and in healthy control subjects.

Detailed description

In detail an oral glucose tolerance test (OGTT) was conducted in women with the PCOS defined by the Rotterdam and the NIH-criteria, as well as in healthy control subjects. In addition 1H-magnetic resonance spectroscopy and Imaging was used for the assessment of the ectopic lipid content in the liver, heart and skeletal muscle. The aim of the present study was to compare the glucose metabolism and the ectopic lipid conent in the liver, heart and muscle between women with the PCOS defined by the NIH-criteria, Rotterdam-criteria and healthy control subjects.

Conditions

• Polycystic Ovary Syndrome
• Glucose Intolerance
• Liver Fat
• Glucose Metabolism Disorders

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Oral glucose tolerance test (OGTT)	For the assessment of glucose metabolism, including beta-cell function and insulin sensitivity an 75g-OGTT was conducted.
OTHER	1H-magnetic resonance spectroscopy	The amount of ectopic lipids in the liver, heart and the skeletal muscle was measured using 1H-magnetic resonance spectroscopy.

Timeline

• Start date: 2012-12-03
• Primary completion: 2015-07-09
• Completion: 2015-07-30
• First posted: 2017-07-02
• Last updated: 2017-07-02

Locations

1 site across 1 country: Austria