NCT03203694

Effects of Walking and Heating on Vascular Function in Diabetic Patients

Restoring Vasodilator Actions of Insulin in Patients With Type 2 Diabetes

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 99 (actual)
• Sponsor: University of Missouri-Columbia · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of the present study is to determine the effects of increased walking and lower body heating on leg vascular function in patients with type 2 diabetes (T2D).

Detailed description

The notion that habitual aerobic exercise increases insulin-induced vasodilation is largely founded on rodent studies, hence the urgent need for human studies, especially in patients with type 2 diabetes (T2D). For example, it remains unknown if increased walking, the most common form of physical activity, enhances skeletal muscle vasodilator actions of insulin in T2D. In addition, the molecular mechanisms by which exercise improves vasoreactivity to insulin have not been examined in humans. The investigators propose that in T2D patients who are sedentary (i.e., the vast majority), increased leg blood flow with walking or local heating signifies a vital strategy to correct vascular insulin resistance. This study will establish whether increased physical activity and associated hemodynamic forces (e.g., shear stress) are a direct form of vascular medicine in humans.

Conditions

• Type 2 Diabetes Mellitus
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Walking: Intervention arm in diabetics	The walking program will consist of 45 minutes of walking (at a moderate pace) 5 days per week for 8 weeks.
OTHER	Walking: No intervention in diabetics	Subjects will be instructed to continue their usual lifestyle for 8 weeks.
OTHER	Walking: Healthy cohort as reference controls	Subjects will be studied at one time only.
BEHAVIORAL	Lower body heating: Intervention arm in healthy subjects	This intervention consists of 60 minutes of lower body heating (40-42 degree C).
BEHAVIORAL	Lower body heating: Intervention arm in diabetics	This intervention consists of 60 minutes of lower body heating (40-42 degree C) 7 days per week for 7 days.
OTHER	Lower body heating: Healthy cohort as reference controls	Subjects will be studied at one time only.

Timeline

• Start date: 2017-12-04
• Primary completion: 2022-03-10
• Completion: 2022-03-10
• First posted: 2017-06-29
• Last updated: 2024-04-04
• Results posted: 2024-04-04

Locations

1 site across 1 country: United States