NCT03202043

The Juice Study: Sensitivity of Skin Carotenoid Status to Detect Change in Intake

Sensitivity of Skin Carotenoid Status to Detect Changes in Intake of Varying Levels of Vegetables

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: USDA Grand Forks Human Nutrition Research Center · Federal
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study is designed to see if drinking a tomato-based vegetable juice will increase skin carotenoids.

Detailed description

The US Dietary Guidelines for Americans recommends that individuals consume approximately 2-4 c of vegetables each day to reduce risk of chronic disease, but current methods for assessing intake are either inaccurate (self-report) or invasive (blood carotenoid levels). Recent research indicates that skin carotenoid status may be a useful biomarker of vegetable intake, but the sensitivity to dose in unknown. In this study, we propose to test the dose-response of skin carotenoids to consumption of 3 different levels of vegetable juice (with a control group receiving water). We will test skin carotenoids in two ways: using resonance Raman spectroscopy (RRS), which we have previously validated, and with a new technique, pressure mediated reflection spectroscopy (RS; the "Veggie Meter"). We will compare the two techniques during an 8-week provided tomato-based juice intervention. Skin carotenoid readings will be compared to blood carotenoid concentrations and single nucleotide polymorphisms (SNPs) of genes related to the uptake, transport, and metabolism of carotenoids will be examined in blood and saliva.

Conditions

• Overweight

Interventions

Type	Name	Description
OTHER	High dose vegetable juice	High dose (13 fl oz) vegetable juice
OTHER	Medium dose vegetable juice	Medium dose (10 fl oz) vegetable juice
OTHER	Low dose vegetable juice	Low dose (5.5 fl oz) vegetable juice
OTHER	Control bottled water	Control (12 fl oz) bottled water

Timeline

• Start date: 2018-04-06
• Primary completion: 2019-05-21
• Completion: 2019-05-21
• First posted: 2017-06-28
• Last updated: 2022-05-16

Locations

1 site across 1 country: United States