NCT03200158

Study on Correlated Factors of Barrier and Immune Function in Stress Related Mucosal Disease (SRMD)

Study on Changes of Barrier and Immune Function in Stress Related Mucosal Disease (SRMD)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 53 (actual)
• Sponsor: Xiuli Zuo · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Accepted

Summary

To study the changes of barrier and immune function in Stress Related Mucosal Disease (SRMD).

Detailed description

38 patients admitted to ICU and 15 healthy volunteers were successively enrolled in this study.The healthy volunteers were treated with endoscopy and biopsy .The 38 patients were treated with bedside gastroscopy and diagnosed with SRMD due to illness. The acute physiology and chronic health evaluation（APACHE）II score were evaluated, malondialdehyde (MDA) as an index of oxygen radical-lipid peroxidation was assessed in the serum. Transforming growth factor(TGF)β1,claudin3, interleukin (IL) 1 and interleukin（IL）10 levels in the gastric mucosa and plasma level of superoxide dismutase(SOD)，Ischemic modified albumin(IMA)and C-reactive protein（CRP）were evaluated.

Conditions

• Stress Related Mucosal Disease

Interventions

Type	Name	Description
OTHER	Endoscopy biopsy and blood	Medical operation

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2017-06-27
• Last updated: 2017-06-27

Locations

1 site across 1 country: China