Trials / Completed
CompletedNCT03199911
Topical Antibiotic Prophylaxis for Eyelids
The Role of Topical Antibiotic Prophylaxis in Eyelid Surgery
- Status
- Completed
- Phase
- Phase 4
- Study type
- Interventional
- Enrollment
- 401 (actual)
- Sponsor
- University of California, San Francisco · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
The investigators propose a prospective randomized control trial testing the hypothesis that routine topical antibiotic prophylaxis does not significantly reduce the rate of infection after eyelid surgery.
Detailed description
The use of prophylactic topical antibiotic therapy after eyelid surgery is widespread. Due to increasing antibiotic resistance, antibiotic-related complications, and healthcare costs, the investigators wish to determine whether prophylactic post-operative antibiotic ointment is truly necessary. After all, existing dermatology literature currently recommends against the routine use of antibiotic ointment after various surgical procedures (e.g. Mohs surgery). The investigators aim to perform a prospective randomized control trial at the University of California, San Francisco. The investigators aim to recruit a total of 400 oculoplastics patients undergoing eyelid surgery or surgery involving peri-orbital incisions from 2017 through 2019.
Conditions
- Antibiotic Side Effect
- Eyelid; Wound
- Eyelid Diseases
- Surgical Wound Infection
- Surgical Wound, Recent
- Surgical Incision
- Skin Cancer Face
- Antibiotic Allergy
- Surgical Site Infection
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Topical Antibiotic Product | Topical antibiotic ointment will be erythromycin or bacitracin. If the patient cannot obtain either (e.g. lack of availability at the pharmacy), bacitracin polymyxin will be prescribed. Allergy to all 3 study drugs means that a patient will be excluded from the study. |
| DRUG | Topical Non-Antibiotic Ointment | Mineral oil/petrolatum-based artificial tear ointment. |
Timeline
- Start date
- 2017-10-02
- Primary completion
- 2019-11-14
- Completion
- 2019-11-14
- First posted
- 2017-06-27
- Last updated
- 2020-07-21
- Results posted
- 2020-07-21
Locations
1 site across 1 country: United States
Regulatory
- FDA-regulated drug study
Source: ClinicalTrials.gov record NCT03199911. Inclusion in this directory is not an endorsement.