NCT03197597

EUpertstrain 4 Study of Bordetella Pertussis Isolates

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 265 (actual)
• Sponsor: University of Turku · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

This study focus on the genetic changes of B. pertussis clinical isolates. For this panels of B. pertussis isolates has been collected during four periods in different European countries.

Detailed description

B. pertussis is considered as a monomorphic pathogen. However, genetic changes have been observed in several antigens (pertussis toxin, pertactin, filamentous haemagglutinin and fimbriae) included in the current acellular pertussis vaccines between vaccine strains and circulating isolates. To study genetic changes in the B. pertussis populations in Europe, four distinct panels have been collected: EUpert I in 1999-2001 including 102 isolates, EUpert II in 2004-2005 including 154 isolates, EUpert III in 2007-2009 including 140 isolates and EUpert IV in 2012-2015 including 265 isolates. Selection criteria have remained unchanged for all four collections, which enables the opportunity to study changes in B. pertussis populations during the last 15 years.

Conditions

• Bordetella Pertussis, Whooping Cough

Interventions

Type	Name	Description
OTHER	Strain isolation from the nasopharynx	B. pertussis strains has been collected from the nasopharynx of the patients during the clinical visit

Timeline

• Start date: 2015-10-12
• Primary completion: 2016-12-31
• Completion: 2016-12-31
• First posted: 2017-06-23
• Last updated: 2017-06-23

Locations

1 site across 1 country: Finland