NCT03193099

Decoding Presymptomatic White Matter Changes in Huntington Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Institut National de la Santé Et de la Recherche Médicale, France · Other Government
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

WIN-HD is a monocentric longitudinal study comparing premanifest Huntingtin (HTT) mutation carriers and non HTT mutation carriers to determine that white-matter atrophy occurs far earlier than clinical onset in HD using Diffusion-weighted Nuclear Magnetic Resonance (N spectroscopy (DWS) and Diffusion Tensor Imaging (DTI). The investigators will recruit up to 20 premanifest HTT mutation carriers (15 completed) and up to 20 non HTT mutation carriers (15 completed). It is important to have those 2 populations in order to compare our results and determine if there are significant white-matter changes far from the onset of HD. Therefore, non HTT mutation carriers will be age and gender matched to premanifest HTT mutation carriers. In order to test the hypothesis, the study has 2 visits with a year interval. This study is based on 4 principal criteria: 1. Imaging criteria 2. Clinical and neurological criteria 3. Psychological criteria 4. Behavioral criteria

Conditions

• Huntington Disease
• White Matter Alterations

Interventions

Type	Name	Description
OTHER	Brain imaging	Volume, DWS and DTI
OTHER	Neurological assessments	UHDRS
BEHAVIORAL	Psychological assessments	STAI (Spielberger state and Trait Anxiety Inventory) A and B, BDI-II (Beck Depression Inventory), MINI (Mini-International Neuropsychiatric Interview) and MINI-SEA (mini Social cognitive and Emotional Assessment)
BEHAVIORAL	Behavioural assessments	Computerized game

Timeline

• Start date: 2017-07-11
• Primary completion: 2019-12-30
• Completion: 2019-12-30
• First posted: 2017-06-20
• Last updated: 2020-02-18

Locations

1 site across 1 country: France