NCT03192891

Stress CMR Perfusion Imaging in the United States (SPINS) Study

Stress CMR Perfusion Imaging in the United States (SPINS) Study. A Society for Cardiovascular Magnetic Resonance (SCMR) Registry Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 2,349 (actual)
• Sponsor: Society for Cardiovascular Magnetic Resonance · Academic / Other
• Sex: All
• Age: 35 Years – 85 Years
• Healthy volunteers: —

Summary

Numerous single-center studies have indicated gadolinium-enhanced stress CMR perfusion imaging has excellent diagnostic accuracy for coronary artery disease and negative clinical event rates, with its diagnostic accuracy exceeding nuclear scintigraphy. However, current prognostic evidence supporting clinical use of stress CMR is limited by study size, single-center settings with a predominance of academic centers, and a lack of "real-world" study design. Large-scale multicenter real-world evidence from a registry will provide the much needed information to guide evidence-based clinical adaptation that benefits patient care.

Detailed description

Randomized multicenter studies have demonstrated the high accuracy of vasodilator stress cardiac magnetic resonance imaging (CMR) in detecting coronary stenoses and in estimating impaired flow reserve in coronary artery disease (CAD). Stress CMR has also been shown in many studies to be an effective cardiac prognosticating method for patients presenting with chest pain syndromes. The American College of Cardiology Foundation and American Heart Association have recommended stress CMR as an appropriate test for evaluation of symptomatic patients with intermediate to high pre-test probability for CAD. However, stress CMR remains an underutilized method in the United States. SPINS (Stress CMR Perfusion Imaging in the United States: A Society for Cardiovascular Resonance Registry Study) is a multicenter observational study of patients with stable chest pain syndromes designed to evaluate the long-term performance of stress CMR for cardiovascular prognosis and to investigate the cost of additional downstream cardiac testing following the index stress CMR.

Conditions

• Myocardial Ischemia

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Stress cardiac magnetic resonance (CMR) perfusion imaging	Gadolinium-enhanced stress CMR perfusion imaging is a tool increasingly used for the risk assessment and diagnosis of coronary artery disease.

Timeline

• Start date: 2016-12-01
• Primary completion: 2019-11-30
• Completion: 2019-11-30
• First posted: 2017-06-20
• Last updated: 2025-12-30
• Results posted: 2025-01-31

Locations

13 sites across 1 country: United States