Trials / Unknown
UnknownNCT03191188
A Pilot Feasibility Trial of Thyroid Hormone Replacement in Dialysis Patients
- Status
- Unknown
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 96 (estimated)
- Sponsor
- University of California, Irvine · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Not accepted
Summary
Hypothyroidism, defined by elevated thyrotropin (TSH) levels, is a common endocrine complication of chronic kidney disease that has been associated with impaired quality of life and cardiovascular complications. While levothyroxine is one of the most frequently prescribed medications in chronic kidney disease patients, little is known about its efficacy and safety in this population. This study will investigate 1) whether levothyroxine adequately lowers thyrotropin (TSH) levels to therapeutic target ranges, and 2) if thyroid hormone replacement improves quality of life and cardiovascular markers, without leading to wasting in dialysis patients.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Levothyroxine Sodium | Thyroid hormone supplement |
| DRUG | Placebo Oral Tablet | Placebo |
Timeline
- Start date
- 2017-07-01
- Primary completion
- 2021-07-01
- Completion
- 2021-07-01
- First posted
- 2017-06-19
- Last updated
- 2021-06-14
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT03191188. Inclusion in this directory is not an endorsement.