NCT03187652

A Prospective Study on the Long-Term Vascular Burden in Thrombotic Thrombocytopenic Purpura Patients

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 35 (estimated)
• Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

A prospective cohort study of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome patients who have presented with their acute episode and are in remission within the last 30 days. They will be followed for 12 months from the time of their initial scan, followed by a long-term follow up study.

Detailed description

The investigators will conduct a prospective cohort study at the London Health Sciences Centre, Ontario, Canada. The investigators will identify 15-30 idiopathic thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome patients who are in remission within the last 30 days. They will be followed for 12 months from the time of their remission. Study procedures include routine laboratory monitoring, biomarker assessments, cardiovascular and neurocognitive functional assessments, and non-invasive imaging studies. The long-term follow-up thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome study will help to assess the mechanisms of vascular injuries, evaluate cardiovascular and cerebrovascular monitoring tools, and generate novel ideas to prevent further vascular injuries.

Conditions

• Thrombotic Thrombocytopenic Purpura

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CT Perfusion Study	Brain and cardiac CT perfusion scan
DIAGNOSTIC_TEST	Echocardiogram	Speckle tracking Echocardiography
DIAGNOSTIC_TEST	neuro-cognitive assessment	Cambridge Brain Sciences neuro-cognitive assessment
DIAGNOSTIC_TEST	MRI	MRI to assess white matter changes

Timeline

• Start date: 2017-01-01
• Primary completion: 2026-01-01
• Completion: 2026-01-01
• First posted: 2017-06-15
• Last updated: 2024-03-13

Locations

1 site across 1 country: Canada