NCT03184974

Open Lung PEEP in Thoracic Surgery

Individualized Open Lung PEEP in Thoracic Surgery: A Prospective Multicenter Observational Study in 17 Spanish Hospitals

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 690 (actual)
• Sponsor: Fundación para la Investigación del Hospital Clínico de Valencia · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

During thoracic surgical procedures, while ventilating with a protective tidal volume, an open lung approach consisting of a recruitment maneuver followed by an individualized positive end-expiratory pressure (PEEP) titrated to best respiratory system compliance (Open-lung PEEP, OL-PEEP) would decrease driving pressure. To test this hypothesis, we performed a multicenter observational study in 17 Spanish teaching hospitals of patients undergoing one lung ventilation (OLV). In addition, we analyzed the association between the driving pressure and the prevalence of postoperative pulmonary complications (PPCs), and finally the association between the individualized PEEP and relevant patient preoperative or intraoperative variables.

Conditions

• Thoracic Surgery
• Ventilation Therapy; Complications

Timeline

• Start date: 2015-10-01
• Primary completion: 2016-10-01
• Completion: 2016-11-01
• First posted: 2017-06-14
• Last updated: 2018-03-07