NCT03181256

Early Detection of Lung Cancer

Early Detection of Lung Cancer in the Medically Underserved Population

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 45 (actual)
• Sponsor: Vanderbilt-Ingram Cancer Center · Academic / Other
• Sex: All
• Age: 55 Years – 80 Years
• Healthy volunteers: —

Summary

This research trial studies the long term follow-up for early detection of lung cancer in current or former smokers. Following up on smokers by collecting and analyzing specimens in the laboratory, performing chest computed tomography (CT) scans, as well as reviewing medical records may help doctors detect lung cancer at an earlier stage.

Detailed description

PRIMARY OBJECTIVES: I. To provide screening for lung cancer in an underserved and high risk population for lung cancer. II. To collect clinical and demographic information and research bio specimens prospectively on high risk individuals. III. To analyze the association between suspected lung cancer risk factors and outcomes such as pre-malignant lesions and diagnosis of lung cancer. IV. To identify and validate biomarkers that are associated with lung cancer risk factors and premalignant lesions. V. To assess the association between patient characteristics and test results to the genetic and histological characteristics of lung preinvasive lesions and cancers. VI. To describe this high-risk cohort and to identify the patients eligible for future clinical trials (e.g. chemoprevention). OUTLINE: Patients are followed up at 1, 2, 3, 4, and 5 years and undergo collection of sputum, nasal epithelium, buccal epithelium, blood, and urine samples. Patients also undergo pulmonary function tests, chest CT, and review of medical records.

Conditions

• Lung Cancer

Interventions

Type	Name	Description
PROCEDURE	Biospecimen Collection	Undergo collection of sputum
PROCEDURE	Biospecimen collection	Undergo collection of nasal epithelium
PROCEDURE	Biospecimen collection	Undergo collection of buccal epithelium
PROCEDURE	Biospecimen collection	Undergo collection of blood
PROCEDURE	Biospecimen collection	Undergo collection of urine
PROCEDURE	Pulmonary Function Test	Undergo pulmonary function test
PROCEDURE	Computed Tomography (CT)	Undergo chest CT
OTHER	Laboratory Biomarker	Correlative studies

Timeline

• Start date: 2017-12-14
• Primary completion: 2023-11-30
• Completion: 2025-12-01
• First posted: 2017-06-08
• Last updated: 2025-10-01

Locations

1 site across 1 country: United States