Trials / Unknown
UnknownNCT03179137
Mitochondrial Bioenergetics and Role in Cellular Damage in Ischemic Myocardium
Pathophysiological Mechanisms Elicited by Ischemia and Metabolic Co-morbidities in Myocardium of Patients With Coronary Artery Disease
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 80 (estimated)
- Sponsor
- University of Split, School of Medicine · Academic / Other
- Sex
- All
- Age
- 50 Years – 85 Years
- Healthy volunteers
- Not accepted
Summary
Cardiac ischemia is a common pathological condition, known to elicit multiple pathological processes at the cellular level. One of the most affected is thought to be cellular metabolism, key for the adequate cardiac function. The aim is to study mitochondrial bioenergetic function, interaction with other cellular systems and influence of several co-morbidities in myocardium of the affected patients.
Detailed description
Coronary artery disease, one of the most common pathologies in the developed world, causes hypoperfusion of myocardial tissue, usually evident by the presence of anginal pain. This myocardial ischemia elicits alterations in normal cardiomyocyte physiology, which gradually deteriorate cellular function, affecting the performance of the entire organ. The condition is frequently further complicated (and aggravated) by the presence of various co-morbidities, such as diabetes mellitus. The primary aim of this study is to investigate the cardiomyocyte bioenergetics and the consequences of potentially reduced mitochondrial metabolic function in ischemic heart, and evaluate the potential contribution of other conditions, primarily ones affecting metabolic homeostasis.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | Standard therapy | Patients with therapy prescribed independent of the study |
Timeline
- Start date
- 2016-10-01
- Primary completion
- 2021-04-01
- Completion
- 2021-10-01
- First posted
- 2017-06-07
- Last updated
- 2020-06-19
Locations
1 site across 1 country: Croatia
Source: ClinicalTrials.gov record NCT03179137. Inclusion in this directory is not an endorsement.